Indian Pediatr. 2005 Dec;42(12):1233-5.

Thyroid dyshormonogenesis.

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Department of Nuclear Medicine, Army hospital R&R Delhi Cantt, 11010, India. kum39@yahoo.com

Abstract

Dyshormonogenesis is an uncommon cause of congenital hypothyroidism. The most common abnormality is absent or insufficient thyroid peroxidase enzyme. Perchlorate discharge test can be used to diagnose thyroid peroxidase deficiency. We report three siblings with hypothyroidism due to thyroid dyshormonogenesis. Early institution of therapy in these patients can prevent mental retardation and other features of hypothyroidism.

PMID:: 16424561; [PubMed - indexed for MEDLINE]

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Iodide Peroxidase

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congenital hypothyroidism - Genetics Home Reference

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