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Genome Biol. 2005;6(13):244. Epub 2006 Jan 3.

Recent developments in membrane-protein structural genomics.

Author information

  • 1Department of Chemistry and Biochemistry, and the National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA. gao@magnet.fsu.edu

Abstract

Recent work has identified the topology of almost all the inner membrane proteins in Escherichia coli, and advances in nuclear magnetic resonance spectroscopy now allow the determination of alpha-helical membrane protein structures at high resolution. Together these developments will help overcome the current limitations of high-throughput determination of membrane protein structures.

PMID:
16420681
[PubMed - indexed for MEDLINE]
PMCID:
PMC1414099
Free PMC Article

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