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Genome Biol. 2005;6(13):R114. Epub 2005 Dec 19.

Discovery of biological networks from diverse functional genomic data.

Author information

  • 1Department of Computer Science, Princeton University, 35 Olden Street, Princeton, NJ 08544, USA. clmyers@princeton.edu

Abstract

We have developed a general probabilistic system for query-based discovery of pathway-specific networks through integration of diverse genome-wide data. This framework was validated by accurately recovering known networks for 31 biological processes in Saccharomyces cerevisiae and experimentally verifying predictions for the process of chromosomal segregation. Our system, bioPIXIE, a public, comprehensive system for integration, analysis, and visualization of biological network predictions for S. cerevisiae, is freely accessible over the worldwide web.

PMID:
16420673
[PubMed - indexed for MEDLINE]
PMCID:
PMC1414113
Free PMC Article

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