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Cell. 2006 Jan 13;124(1):35-46.

Protein sensors for membrane sterols.

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  • 1Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. joe.goldstein@utsouthwestern.edu

Abstract

Cholesterol is an essential component of animal cell membranes, and its concentration is tightly controlled by a feedback system that operates at transcriptional and posttranscriptional levels. Here, we discuss recent advances that explain how cells employ an ensemble of membrane-embedded proteins to monitor sterol concentrations and adjust sterol synthesis and uptake.

PMID:
16413480
[PubMed - indexed for MEDLINE]
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