Cell. 2006 Jan 13;124(1):15-7.

Pathogens reWritE Rho's rules.

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University of Cambridge, Department of Pathology, Cambridge CB2 1QP, UK.

Abstract

Many bacterial pathogens use a specialized "type III" secretion system to deliver virulence effector proteins into host mammalian cells. In this issue of Cell, Alto et al. (2006) describe a new family of effectors that share a WxxxE sequence motif. These effectors directly stimulate host signaling pathways by mimicking activated Ras-like cellular GTPases.

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Cell. 2006 Jan 13;124(1):133-45.

PMID:: 16413475; [PubMed - indexed for MEDLINE]

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Identification of a bacterial type III effector family with G protein mimicry functions. [Cell. 2006]
Identification of a bacterial type III effector family with G protein mimicry functions.
Alto NM, Shao F, Lazar CS, Brost RL, Chua G, Mattoo S, McMahon SA, Ghosh P, Hughes TR, Boone C, et al. Cell. 2006 Jan 13; 124(1):133-45.
Multiple activities of the plant pathogen type III effector proteins WtsE and AvrE require WxxxE motifs. [Mol Plant Microbe Interact. 2009]
Multiple activities of the plant pathogen type III effector proteins WtsE and AvrE require WxxxE motifs.
Ham JH, Majerczak DR, Nomura K, Mecey C, Uribe F, He SY, Mackey D, Coplin DL. Mol Plant Microbe Interact. 2009 Jun; 22(6):703-12.
Review Exploitation of eukaryotic ubiquitin signaling pathways by effectors translocated by bacterial type III and type IV secretion systems. [PLoS Pathog. 2007]
Review Exploitation of eukaryotic ubiquitin signaling pathways by effectors translocated by bacterial type III and type IV secretion systems.
Angot A, Vergunst A, Genin S, Peeters N. PLoS Pathog. 2007 Jan; 3(1):e3.
Review Structural mimicry in bacterial virulence. [Nature. 2001]
Review Structural mimicry in bacterial virulence.
Stebbins CE, Galán JE. Nature. 2001 Aug 16; 412(6848):701-5.
Review Effector proteins of phytopathogenic bacteria: bifunctional signals in virulence and host recognition. [Curr Opin Microbiol. 2000]
Review Effector proteins of phytopathogenic bacteria: bifunctional signals in virulence and host recognition.
Kjemtrup S, Nimchuk Z, Dangl JL. Curr Opin Microbiol. 2000 Feb; 3(1):73-8.

See reviews... See all...

Cited by 2 PubMed Central articles

Structure of Shigella IpgB2 in complex with human RhoA: implications for the mechanism of bacterial guanine nucleotide exchange factor mimicry. [J Biol Chem. 2010]
Structure of Shigella IpgB2 in complex with human RhoA: implications for the mechanism of bacterial guanine nucleotide exchange factor mimicry.
Klink BU, Barden S, Heidler TV, Borchers C, Ladwein M, Stradal TE, Rottner K, Heinz DW. J Biol Chem. 2010 May 28; 285(22):17197-208. Epub 2010 Apr 2.
Macropinocytosis in Shiga toxin 1 uptake by human intestinal epithelial cells and transcellular transcytosis. [Am J Physiol Gastrointest Live...]
Macropinocytosis in Shiga toxin 1 uptake by human intestinal epithelial cells and transcellular transcytosis.
Malyukova I, Murray KF, Zhu C, Boedeker E, Kane A, Patterson K, Peterson JR, Donowitz M, Kovbasnjuk O. Am J Physiol Gastrointest Liver Physiol. 2009 Jan; 296(1):G78-92. Epub 2008 Oct 30.

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