OBJECTIVES: To assess the efficacy and safety of the pollen extract preparation Prostat/Poltit in the treatment of patients with chronic nonbacterial prostatitis/chronic pelvic pain syndrome. METHODS: In a double-blind study, 60 patients between 20 and 55 years old with chronic nonbacterial prostatitis/chronic pelvic pain syndrome were randomized to receive Prostat/Poltit or placebo for 6 months. The patients had been symptomatic for more than 6 months without response to any given therapy. The patients were evaluated at the start of the treatment and after 6 months of treatment with the help of a symptom questionnaire covering the symptoms in seven pain locations, five voiding symptoms, three storage symptoms, and four sex-related symptoms. RESULTS: The overall clinical evaluation of the treatment result showed that after treatment for 6 months more patients taking Prostat/Poltit were cured or improved than patients taking placebo. No adverse reactions to the treatment were found. CONCLUSIONS: Prostat/Poltit is superior to placebo in providing symptomatic relief in men with chronic nonbacterial prostatitis/chronic pelvic pain syndrome.