Your browser version may not work well with NCBI's Web applications. More information here...
1: J Chromatogr A. 2006 Feb 24;1107(1-2):165-74. Epub 2006 Jan 18.Click here to read Links

Application of cellulose and amylose arylcarbamates as chiral selectors in counter-current chromatography.

Pérez E, Santos MJ, Minguillón C.

Institut de Recerca Biomèdica-Parc Científic de Barcelona, Josep Samitier, 1-5, E-08028 Barcelona, Spain.

Here we studied the applicability of cellulose and amylose tris(3,5-dimethylphenylcarbamate) as chiral selectors for the separation of enantiomers by counter-current chromatography (CCC). A variety of organic/aqueous biphasic solvent systems and eight racemic analytes of acidic, neutral, and basic nature were tested for this purpose. Classical elution mode and pH-zone-refining displacement conditions were used. Partial enantioseparation of pindolol and warfarin was achieved in methyl isobutyl ketone (MIBK)/aqueous solution and methyl tert-butyl ether (MTBE)/aqueous solution, respectively. For these two racemates enantiomeric excess values from 84% to 97% were achieved under the best conditions tested. However, resolution by CCC was not achieved for propranolol, naproxen and N-(3,5-dinitrobenzoyl)-(+/-)-leucine, easily separated in HPLC by the same selectors.

PMID: 16412450 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Acebutolol (Sectral, Tenormin, Betoptic, ...)

    How do beta blockers compare in treating patients with hypertension?

  • Warfarin (Coumadin® )

    Warfarin is used to prevent blood clots from forming or growing larger in your blood and blood vessels. It is prescribed for people with certain types of irregular heartbeat, people with prosthetic (replacement or mechan...

  • Pindolol (Visken® )

    Pindolol is used to treat high blood pressure. It works by relaxing your blood vessels so your heart doesn't have to pump as hard.

  • » See all 5 drug reports ...
  • Source: AHFS Consumer Medication Information