Display Settings:

Format

Send to:

Choose Destination
J Cutan Pathol. 2006 Feb;33 Suppl 1:10-7.

Pathobiology of CD30+ cutaneous T-cell lymphomas.

Author information

  • Laboratory Medicine, Yamins 309, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA. mkadin@bidmc.harvard.edu

Abstract

CD30+ cutaneous lymphoproliferative disorders include lymphomatoid papulosis (LyP) and anaplastic large cell lymphoma (ALCL). LyP is associated with development of lymphoma in nearly 20% of patients. Herein is reviewed the clonal relationship of LyP to malignant lymphoma, the concept of a common stem cell for LyP and associated lymphomas, and the role of genetic instability in lymphomagenesis. The possible role of the CD30+ cell as a regulatory T-cell is introduced and a model for progression of LyP to ALCL is illustrated.

PMID:
16412208
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Blackwell Publishing
    Loading ...
    Write to the Help Desk