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Nature. 1992 Aug 6;358(6386):470-6.

The gene lin-3 encodes an inductive signal for vulval development in C. elegans.

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  • 1Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91125.


The lin-3 gene is necessary for induction of the Caenorhabditis elegans vulva by the anchor cell. It encodes a molecule similar to epidermal growth factor and to transforming growth factor-alpha and acts through the epidermal growth factor receptor homologue let-23. Expression of lin-3 in the anchor cell stimulates vulval induction; lin-3 may encode the vulval inducing signal.

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