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Bioinformatics. 2006 Mar 15;22(6):771-2. Epub 2006 Jan 12.

Maximum likelihood estimates of allele frequencies and error rates from samples of related individuals by gene counting.

Author information

  • 1Department of Medical Informatics, University of Utah, 391 Chipeta Way, Suite D, Salt Lake City, 84108, USA. alun@genepi.med.utah.edu

Abstract

SUMMARY:

Graphical modeling is used to extend the gene counting method to compute maximum likelihood estimates of allele frequencies for samples of individuals related in extended pedigrees. Genotypes may be missing or partially observed, and error rates can be simultaneously estimated.

AVAILABILITY:

The Java classes and Javadocs pages for \mathsf\hbox GeneCountAlleles can be obtained from bioinformatics.med.utah.edu/~alun, which also has more information on its use and file formats.

PMID:
16410318
[PubMed - indexed for MEDLINE]
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