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1: Nat Chem Biol. 2005 Nov;1(6):300-3. Links

Chemical biology at the crossroads of molecular structure and mechanism.

Doudna JA.

Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94705, USA. doudna@berkeley.edu

Chemical insight into biological function is the holy grail of structural biology. Small molecules are central players as building blocks, effectors and probes of macromolecular structure and function.

PMID: 16408062 [PubMed - indexed for MEDLINE]