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Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):538-42. Epub 2006 Jan 5.

High-speed microfluidic differential manometer for cellular-scale hydrodynamics.

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  • 1Division of Engineering and Applied Sciences, Harvard University, Pierce Hall, Cambridge, MA 02138, USA.


We propose a broadly applicable high-speed microfluidic approach for measuring dynamical pressure-drop variations along a micrometer-sized channel and illustrate the potential of the technique by presenting measurements of the additional pressure drop produced at the scale of individual flowing cells. The influence of drug-modified mechanical properties of the cell membrane is shown. Finally, single hemolysis events during flow are recorded simultaneously with the critical pressure drop for the rupture of the membrane. This scale-independent measurement approach can be applied to any dynamical process or event that changes the hydrodynamic resistance of micro- or nanochannels.

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