Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Neurosci. 2006 Feb;29(2):116-24. Epub 2006 Jan 6.

Orbitofrontal cortex, decision-making and drug addiction.

Author information

  • 1Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, HSF-2 S251, Baltimore, MD 21201, USA. schoenbg@schoenbaumlab.org

Abstract

The orbitofrontal cortex, as a part of prefrontal cortex, is implicated in executive function. However, within this broad region, the orbitofrontal cortex is distinguished by its unique pattern of connections with crucial subcortical associative learning nodes, such as basolateral amygdala and nucleus accumbens. By virtue of these connections, the orbitofrontal cortex is uniquely positioned to use associative information to project into the future, and to use the value of perceived or expected outcomes to guide decisions. This review will discuss recent evidence that supports this proposal and will examine evidence that loss of this signal, as the result of drug-induced changes in these brain circuits, might account for the maladaptive decision-making that characterizes drug addiction.

PMID:
16406092
[PubMed - indexed for MEDLINE]
PMCID:
PMC2430629
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk