An improved synthesis of resveratrol. [Nat Prod Res. 2006]

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1: Nat Prod Res. 2006 Mar;20(3):247-52. Links

An improved synthesis of resveratrol.

Farina A, Ferranti C, Marra C.

Dipartimento di Chimica dell'Università "La Sapienza", Piazzale Aldo Moro 5, 00185 Roma, Italy.

In this article we report an improved total synthesis of resveratrol, increasing the overall yield from 22 to 71%. The synthesis reported in our previous publication was made up of two fundamental steps: a Wittig reaction and a Heck coupling. Here we studied these steps separately to increase the individual yields. The yield of the Wittig reaction was increased up to 98%; however, we could not find better reaction conditions for the Heck coupling than those reported in the previous article.

PMID: 16401555 [PubMed - indexed for MEDLINE]

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An improved synthesis of resveratrol.

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