Accelerator mass spectrometry for biomedical research

Methods Enzymol. 2005:402:423-43. doi: 10.1016/S0076-6879(05)02014-8.

Abstract

Accelerator mass spectrometry (AMS) is the most sensitive method for detecting and quantifying rare long-lived isotopes with high precision. In this chapter, we review the principles underlying AMS-based biomedical studies, focusing on important practical considerations and experimental procedures needed for the detection and quantitation of (14)C- and (3)H-labeled compounds in various experiment types.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Carbon Radioisotopes / analysis
  • DNA / analysis*
  • Humans
  • Mass Spectrometry / instrumentation*
  • Mass Spectrometry / methods*
  • Particle Accelerators / instrumentation
  • Proteins / analysis*
  • Tritium / analysis

Substances

  • Carbon Radioisotopes
  • Proteins
  • Tritium
  • DNA