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Am J Cardiol. 2005 Dec 19;96(12A):19L-23L. Epub 2005 Oct 5.

Hyponatremia in patients with heart failure.

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  • 1Department of Cardiovascular and Respiratory Sciences, La Sapienza University, Rome, Italy.


Mild hyponatremia is encountered frequently in patients hospitalized for worsening heart failure. Admission plasma sodium concentration appears to be an independent predictor of increased mortality after discharge and rehospitalization. Recent studies have suggested that correction of hyponatremia may be associated with improved survival. This hypothesis is currently being studied in large prospective randomized clinical trials.

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