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Dev Cell. 2006 Jan;10(1):8-9.

Genomic regulation of Hox collinearity.

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  • 1Department of Zoology, University of Florida, P.O. Box 118525, Gainesville, Florida 32611, USA.


During vertebrate limb development, Hoxd genes are transcribed in two temporal phases; an early wave controls growth and polarity up to the forearm and a late wave patterns the digits. In this issue of Developmental Cell, Tarchini and Duboule (2006) report that two opposite regulatory modules direct early collinear expression of Hoxd genes.

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