Cancer Res. 2006 Jan 1;66(1):2-5.

EphB/EphrinB receptors and Wnt signaling in colorectal cancer.

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Hubrecht Laboratory and Centre for Biomedical Genetics, Utrecht, The Netherlands.

Abstract

Eph receptors and their ephrin ligands mediate cell repulsion during embryonic development. In the intestinal epithelium, EphB receptors are Wnt signaling target genes that control cell compartmentalization along the crypt axis. Recent findings have shown that this family of receptors are key players during colorectal cancer progression. Here, we review the current knowledge of the EphB/ephrinB system in the intestinal epithelium and we discuss their tumor suppressor role in the context of the multistep progression of colorectal cancer.

PMID:: 16397205; [PubMed - indexed for MEDLINE]

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EphB/EphrinB receptors and Wnt signaling in colorectal cancer.
EphB/EphrinB receptors and Wnt signaling in colorectal cancer.
Cancer Res. 2006 Jan 1 ;66(1):2-5.

PubMed
EphB receptor activity suppresses colorectal cancer progression.
EphB receptor activity suppresses colorectal cancer progression.
Nature. 2005 Jun 23 ;435(7045):1126-30.

PubMed
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorecta...
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.
Cell. 2002 Oct 18 ;111(2):241-50.

PubMed
A new identity for the elusive intestinal stem cell.
A new identity for the elusive intestinal stem cell.
Nat Genet. 2008 Jul ;40(7):818-9.

PubMed
Eph-ephrin signalling in adult tissues and cancer.
Eph-ephrin signalling in adult tissues and cancer.
Curr Opin Cell Biol. 2008 Apr ;20(2):194-200. Epub 2008 Mar 18 .

PubMed

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EphB/EphrinB receptors and Wnt signaling in colorectal cancer.

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