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EphB/EphrinB receptors and Wnt signaling in colorectal cancer.
Hubrecht Laboratory and Centre for Biomedical Genetics, Utrecht, The Netherlands.
Eph receptors and their ephrin ligands mediate cell repulsion during embryonic development. In the intestinal epithelium, EphB receptors are Wnt signaling target genes that control cell compartmentalization along the crypt axis. Recent findings have shown that this family of receptors are key players during colorectal cancer progression. Here, we review the current knowledge of the EphB/ephrinB system in the intestinal epithelium and we discuss their tumor suppressor role in the context of the multistep progression of colorectal cancer.
PMID: 16397205 [PubMed - indexed for MEDLINE]
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Cited by 4 PubMed Central articles
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The genomics of colorectal cancer: state of the art.
Beggs AD, Hodgson SV.
Curr Genomics. 2008 Mar; 9(1):1-10.
[Curr Genomics. 2008]
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Germline EPHB2 receptor variants in familial colorectal cancer.
Zogopoulos G, Jorgensen C, Bacani J, Montpetit A, Lepage P, Ferretti V, Chad L, Selvarajah S, Zanke B, Hudson TJ, et al.
PLoS One. 2008 Aug 6; 3(8):e2885. Epub 2008 Aug 6.
[PLoS One. 2008]
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Transcriptional modulation of genes encoding structural characteristics of differentiating enterocytes during development of a polarized epithelium in vitro.
Halbleib JM, Sääf AM, Brown PO, Nelson WJ.
Mol Biol Cell. 2007 Nov; 18(11):4261-78. Epub 2007 Aug 15.
[Mol Biol Cell. 2007]
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