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Thorax. 2006 Jan;61(1):54-6.

Screening for lung cancer using low dose CT scanning: results of 2 year follow up.

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  • 1Department of Medicine, Royal College of Surgeons in Ireland, Dublin. rmacredmond@rcsi.ie

Abstract

BACKGROUND:

Screening with low dose chest computed tomographic scanning (LDCCT) may improve survival by identifying early asymptomatic lung cancer.

METHODS:

Four hundred and forty nine high risk subjects were screened with serial LDCCT scanning over 2 years. Fine needle aspiration biopsy was recommended for non-calcified nodules (NCNs) of >10 mm diameter or demonstrating interval growth.

RESULTS:

NCNs were identified in 111 subjects (24.7%), three of which were lung cancer. The overall prevalence (0.4%) and incidence (1.3%) rates of lung cancer detection were low. Three of the six lung cancers detected in the study were stage 1 non-small cell lung cancer; the remainder were unresectable central tumours. By contrast, eight subjects developed extrathoracic malignancy during the study period and other incidental pathology was noted in 221 subjects (49.2%). Smoking cessation rates at 19% were higher than in the general population, but 60.8% of subjects continued to smoke.

CONCLUSION:

LDCCT scanning is useful in detecting early peripheral non-small cell lung cancers but its usefulness as a screening tool is limited by low specificity and by poor sensitivity for central tumours.

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PMID:
16396954
[PubMed - indexed for MEDLINE]
PMCID:
PMC2080704
Free PMC Article
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