Rapid Commun Mass Spectrom. 2006;20(3):481-6.

Differentiation of monoiodothyronines using electrospray ionization tandem mass spectrometry.

Source

Division of Biology, Kansas State University, Manhattan, KS 66506-4901, USA. ytz@ksu.edu

Abstract

In this work two monoiodothyronines, 3-T1 and 3'-T1, have been analyzed using electrospray ionization tandem mass spectrometry (ESI-MS/MS). Fragmentation patterns were proposed based on our data obtained by ESI-MS/MS. MS2 spectra in either negative or positive ion mode can be used to differentiate 3-T1 and 3'-T1. Based on the relative abundance of fragment ions in MS2 spectra in the negative ion mode, quantification of the 3-T1 and 3'-T1 isomers in mixtures is achieved without prior separation. Solid-phase extraction in combination with ESI-MS/MS provides a practicable procedure that can be used to determine the molar ratio of 3-T1 and 3'-T1 in human serum with an error less than 3%. The detection limits for 3-T1 and 3'-T1 were 0.5 and 0.7 pg/microL, respectively.

PMID:: 16395738; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

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Research Support, N.I.H., Extramural

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EY000952/EY/NEI NIH HHS/United States

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