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Curr Opin Crit Care. 2006 Feb;12(1):32-6.

Designing clinical trials in acute lung injury/acute respiratory distress syndrome.

Author information

  • 1The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, PA 15261, USA. huangdt@ccm.upmc.edu

Abstract

PURPOSE OF REVIEW:

To review the implications of recent literature for clinical trial design in acute lung injury/acute respiratory distress syndrome (ARDS).

RECENT FINDINGS:

Refinement of acute lung injury/acute respiratory distress syndrome diagnostic criteria and study enrollment criteria, greater efforts to define usual care appropriately, and balancing of efficacy and effectiveness design principles will be key components of future trials.

SUMMARY:

Clinical trial design in acute lung injury/acute respiratory distress syndrome faces many challenges. Although we have learned much from past trials, persistent design dilemmas must be addressed for future trials.

PMID:
16394781
[PubMed - indexed for MEDLINE]
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