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Biol Pharm Bull. 2006 Jan;29(1):177-9.

Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri.

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  • 1Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.


Methyl brevifolincarboxylate (1) isolated from the leaves of Phyllanthus niruri L. showed a vasorelaxant effect on rat aortic rings. Compound 1 exhibited slow relaxation activity against norepinephrine (NE)-induced contractions of rat aorta with or without endothelium. The compound did not affect contractions induced by a high concentration (60 mM) of K+, whereas it inhibited NE-induced vasocontraction in the presence of nicardipine. These results suggest that the inhibition of NE-induced vasocontraction by compound 1 is in part attributable to a decrease in [Ca2+]i through receptor-operated Ca2+ channels.

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