A cluster of expressed zinc finger protein genes i...[Genomics. 1992]

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1: Genomics. 1992 Jul;13(3):845-8. Links

A cluster of expressed zinc finger protein genes in the pericentromeric region of human chromosome 10.

Rousseau-Merck MF, Tunnacliffe A, Berger R, Ponder BA, Thiesen HJ.

INSERM U. 301 Hôpital Saint-Louis, Paris, France.

Three members of the human zinc finger Krüppel family, ZNF11/KOX2, ZNF22/KOX15, and ZNF25/KOX19, have been regionally localized to the pericentromeric region of chromosome 10 by in situ chromosomal hybridization and somatic cell hybrid analysis. ZNF25/KOX19 is located centromeric to a breakpoint in chromosome band 10q11.2 in the chromosome region 10p11.2-q11.2, whereas ZNF22/KOX15 maps distal to it in band 10q11.2. Sequences hybridizing to the KOX2 probe are found at two loci, ZNF11A and ZNF11B, that map proximal and distal to the 10q11.2 breakpoint, respectively. The two ZNF11 loci probably represent two related sequences in 10p11.2-q11.2. This cluster of ZNF/KOX genes is of particular interest since the loci for multiple endocrine neoplasia type 2A and 2B (MEN2A and MEN2B) syndromes have been assigned to this region by linkage analysis.

PMID: 1639412 [PubMed - indexed for MEDLINE]

Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution.
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[Nucleic Acids Res. 1993]
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[Hum Genet. 1991]
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[Hum Genet. 1993]
ReviewLocalization of the gene for MEN 2A.
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[Henry Ford Hosp Med J. 1992]
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Cited by 6 PubMed Central articles

A comprehensive catalog of human KRAB-associated zinc finger genes: insights into the evolutionary history of a large family of transcriptional repressors.
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Construction of an approximately 700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3.
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[Genome Res. 1998]
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[EMBO J. 1993]
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Cited by 6 PubMed Central articles

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