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FEBS Lett. 1992 Jul 27;307(1):55-61.

SH3--an abundant protein domain in search of a function.

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  • 1European Molecular Biology Laboratory, Heidelberg, Germany.


Src-homology 3 is a small protein domain of about 60 amino acid residues. It is probably made of beta-sheets. SH3 is present in a large number of eukaryotic proteins which are involved in signal transduction, cell polarization and membrane-cytoskeleton interactions. Here we review its occurrence and discuss possible functions of this domain.

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