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FEBS Lett. 1992 Jul 27;307(1):122-7.

Apoptosis. Biochemical events and relevance to cancer chemotherapy.

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  • 1Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.


Two distinct pathways for cell death exist. Compared to necrotic death, physiological or apoptotic cell death is an active suicidal process that consists of a cascade of well-regulated synthetic events. Participation of specific genes in apoptosis, and its possible molecular regulation, are considered in order to investigate the mechanism of cell death induced by some cancer chemotherapeutic agents.

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