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    Sci STKE. 2006 Jan 3;2006(316):pe1.

    The significance of interferon-gamma-triggered internalization of tight-junction proteins in inflammatory bowel disease.

    Chiba H, Kojima T, Osanai M, Sawada N.

    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan. hidchiba@sapmed.ac.jp

    Disruption of the epithelial barrier function of tight junctions by the proinflammatory cytokine interferon (IFN)-gamma plays a fundamental role in the pathogenesis of inflammatory bowel disease and other gastrointestinal disorders, but its precise mechanism has not been established. This Perspective provides an overview of how IFN-gamma triggers barrier dysfunction and bacterial translocation in intestinal epithelial cells, and highlights the roles of internalization of tight-junction transmembrane proteins, as well as rearrangements of the cortical actin cytoskeleton, in intestinal inflammation.

    PMID: 16391178 [PubMed - indexed for MEDLINE]

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