J Infect Dis. 2006 Feb 1;193(3):451-4. Epub 2005 Dec 28.

GB virus C replicates in primary T and B lymphocytes.

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Research Service and Department of Internal Medicine, Saint Louis University Hospital and St. Louis Veterans Affairs Medical Center, MO 63110, USA. georgesl@slu.edu

Abstract

GB virus C (GBV-C) infection is common in humans and may persist for decades, although most infected persons clear the virus and subsequently develop antibodies to the envelope glycoprotein. GBV-C replicates in peripheral blood mononuclear cells (PBMCs) and CD4(+) T lymphocytes in vitro, and depletion of CD4(+) T lymphocytes has been proposed as the reason for clearance of GBV-C among persons positive for human immunodeficiency virus. We identified GBV-C RNA in purified CD4(+) and CD8(+) T lymphocytes and CD19(+) B lymphocytes removed ex vivo from infected donors and found that GBV-C replicated in vitro in these PBMC subsets, suggesting that GBV-C is a panlymphotropic virus.

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GB virus C replicates in primary T and B lymphocytes.
GB virus C replicates in primary T and B lymphocytes.
J Infect Dis. 2006 Feb 1 ;193(3):451-4. Epub 2005 Dec 28 .

PubMed
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GB virus C replicates in primary T and B lymphocytes.

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