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Bioorg Med Chem Lett. 2006 Mar 15;16(6):1601-4. Epub 2006 Jan 4.

Synthesis and evaluation of an N-acylated photoactivatable analogue of glutathione as probe for glutathione-utilizing enzymes.

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  • 1Laboratoire d'Ingénierie Moléculaire et Biochimie Pharmacologique, Université Paul Verlaine-Metz, 1 boulevard Arago, 57078 METZ Cedex 3, France.

Abstract

The first synthesis of an N-acylated photoactivatable analogue of reduced glutathione is described. N-(4-Benzoylbenzoyl)glutathione (8) was found to be an inhibitor and a photoaffinity probe of purified rat liver glutathione S-transferases.

PMID:
16387494
[PubMed - indexed for MEDLINE]
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