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Transplant Proc. 2005 Dec;37(10):4393-6.

Fulminant hepatic failure from herpes simplex virus: post liver transplantation acyclovir therapy and literature review.

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  • 1University of Cincinnati, Division for Digestive Diseases, Cincinnati, Ohio, USA.

Abstract

INTRODUCTION:

Herpes simplex virus (HSV) is seen throughout the world and can be treated with acyclovir. We present a case of fulminant hepatic failure (FHF) as a result of disseminated HSV infection in a pregnant patient during the second trimester.

METHODS:

The medical records of a patient suffering from HSV-related fulminant hepatic failure were collected. A review of the literature was collected and reported.

RESULTS:

A previously healthy female presented with fulminant hepatic failure at a local emergency room complaining of a 5-day history of fever, nausea, vomiting, and right side abdominal pain that radiated to the back. She was diagnosed with fulminant hepatic failure and progressed into a coma. The patient underwent orthotopic liver transplantation (OLT) prior to the diagnosis of HSV and then treated successfully with acyclovir.

CONCLUSION:

Treatment of HSV fulminant hepatitis is dependent up on early suspicion and prompt intervention. In addition, antiviral therapy may need to be lifelong.

PMID:
16387129
[PubMed - indexed for MEDLINE]
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