Format

Send to:

Choose Destination
See comment in PubMed Commons below
Exp Eye Res. 2006 Apr;82(4):545-57. Epub 2006 Jan 4.

'What controls aqueous humour outflow resistance?'.

Author information

  • 1Department of Biomedical Engineering, Northwestern University, TECH E378, 2145 Sheridan Road, Evanston, IL 60208, USA. mj-johnson2@northwestern.edu

Abstract

The bulk of aqueous humour outflow resistance is generated in or near the inner wall endothelium of Schlemm's canal in normal eyes, and probably also in glaucomatous eyes. Fluid flow through this region is controlled by the location of the giant vacuoles and pores found in cells of the endothelium of Schlemm's canal, but the flow resistance itself is more likely generated either in the extracellular matrix of the juxtacanalicular connective tissue or the basement membrane of Schlemm's canal. Future studies utilizing in vitro perfusion studies of inner wall endothelial cells may give insights into the process by which vacuoles and pores form in this unique endothelium and why inner wall pore density is greatly reduced in glaucoma.

PMID:
16386733
[PubMed - indexed for MEDLINE]
PMCID:
PMC2892751
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk