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Clin Sports Med. 1992 Jul;11(3):533-78.

Cell-matrix response in tendon injury.

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  • 1Department of Orthopaedic Surgery, Georgetown University, Washington, DC.


The healing response after tendon injury is defined by cell matrix adaptive capability. There are distinct macrotraumatic and microtraumatic injury patterns and a spectrum of pathologic responses from inflammation to tissue degeneration, as characterized by the tendinosis phenomenon. Epigenetic and genetic factors govern recovery from tendon injury. The potential for future modulation of injury repair by protein mediators or growth factors appears promising.

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