Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cancer Lett. 1992 Jul 10;64(3):249-56.

The growth inhibitory action of melatonin on human breast cancer cells is linked to the estrogen response system.

Author information

  • 1Tulane University, School of Medicine, Department of Anatomy, New Orleans, Louisiana 70112.

Abstract

The pineal hormone, melatonin, was examined for its capacity to modulate the proliferation of a panel of human breast cancer cell lines. Melatonin inhibited, to a varying extent, the proliferation of all three estrogen-responsive cell lines, but had no effect on estrogen-insensitive breast tumor cell lines. Melatonin was also able to specifically block estrogen-induced proliferation in MCF-7 breast cancer cells. However, this action was abolished in the presence of tamoxifen. Therefore, it appears that the antiproliferative effects of melatonin are mediated through the estrogen-response pathway.

PMID:
1638517
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk