Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Clin Virol. 2006 Feb;35(2):206-9. Epub 2005 Dec 27.

Neonatal screening for congenital cytomegalovirus infection and hearing loss.

Author information

  • 1Istituto di Virologia, Universit√† di Milano, Via C. Pascal 38, 20133 Milano, Italy. maria.barbi@unimi.it

Abstract

BACKGROUND:

Congenital cytomegalovirus infection causes 20-30% of congenital sensorineural hearing loss (SNHL) cases. Early identification of CMV attributable cases and their successful treatment are often hampered by the late appearance of the damage in a high proportion of children both symptomatic and asymptomatic at birth.

OBJECTIVE:

To discuss the feasibility of a screening program aimed at finding congenitally infected babies followed by their audiological monitoring.

STUDY DESIGN:

Opinion-review article.

RESULTS AND CONCLUSIONS:

Frequency and severity of hearing loss due to congenital CMV suggest it maybe worthwhile setting up neonatal screening campaigns. Structures where SNHL can be diagnosed and treated exist already in many countries as part of universal neonatal audiological screening schemes. A test based on viral DNA extraction from neonatal dried blood spots on Guthrie cards and its amplification by means of a nested PCR (DBS test) seems to offer the best characteristics for use in screening. Clearly it will be necessary to calculate whether the costs of screening, diagnosis and follow-up, and the financial and emotional burden on the families of infected children, are up to the potential gain.

PMID:
16384745
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk