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Ann N Y Acad Sci. 2005 Nov;1059:76-85.

Regulation of cancer cell survival by Par-4.

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  • 1Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536, USA.


Prostate apoptosis response-4 (Par-4) is a unique pro-apoptotic protein that selectively induces apoptosis in cancer cells. Moreover, Par-4 sensitizes cells to the action of diverse apoptotic stimuli and causes tumor regression. This review discusses the prominent structural and functional features of Par-4 and the multiple levels of regulation of its apoptotic function, all of which can be utilized to develop targeted cancer therapy.

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