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Nucleic Acids Res. 2006 Jan 1;34(Database issue):D489-94.

FlyRNAi: the Drosophila RNAi screening center database.

Author information

  • 1Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. iflockha@genetics.med.harvard.edu

Abstract

RNA interference (RNAi) has become a powerful tool for genetic screening in Drosophila. At the Drosophila RNAi Screening Center (DRSC), we are using a library of over 21,000 double-stranded RNAs targeting known and predicted genes in Drosophila. This library is available for the use of visiting scientists wishing to perform full-genome RNAi screens. The data generated from these screens are collected in the DRSC database (http://flyRNAi.org/cgi-bin/RNAi_screens.pl) in a flexible format for the convenience of the scientist and for archiving data. The long-term goal of this database is to provide annotations for as many of the uncharacterized genes in Drosophila as possible. Data from published screens are available to the public through a highly configurable interface that allows detailed examination of the data and provides access to a number of other databases and bioinformatics tools.

PMID:
16381918
[PubMed - indexed for MEDLINE]
PMCID:
PMC1347476
Free PMC Article

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