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Nucleic Acids Res. 2006 Jan 1;34(Database issue):D257-60.

SMART 5: domains in the context of genomes and networks.

Author information

  • 1EMBL, Meyerhofstrasse 1, 69012 Heidelberg, Germany.

Abstract

The Simple Modular Architecture Research Tool (SMART) is an online resource (http://smart.embl.de/) used for protein domain identification and the analysis of protein domain architectures. Many new features were implemented to make SMART more accessible to scientists from different fields. The new 'Genomic' mode in SMART makes it easy to analyze domain architectures in completely sequenced genomes. Domain annotation has been updated with a detailed taxonomic breakdown and a prediction of the catalytic activity for 50 SMART domains is now available, based on the presence of essential amino acids. Furthermore, intrinsically disordered protein regions can be identified and displayed. The network context is now displayed in the results page for more than 350 000 proteins, enabling easy analyses of domain interactions.

PMID:
16381859
[PubMed - indexed for MEDLINE]
PMCID:
PMC1347442
Free PMC Article

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