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J Clin Immunol. 2005 Nov;25(6):534-40.

NKG2D in NK and T cell-mediated immunity.

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  • 1Department of Microbiology & Immunology and Cancer Research Institute, University of California-San Francisco, 513 Parnassus Avenue, HSE1001G, San Francisco, CA 94143, USA.


One of the best characterized NK cell receptors is NKG2D, a highly conserved C-type lectin-like membrane glycoprotein expressed on essentially all NK cells, as well as on gammadelta-TcR+ T cells and alphabeta-TcR+ CD8+ T cells, in humans and mice. Here we review recent studies implicating NKG2D in T cell and NK cell-mediated immunity to viruses and tumors, and its potential role in autoimmune diseases and allogeneic bone marrow transplantation.

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