J Psychiatry Neurosci. 1992 Jun;17(2):78-80.

Sodium valproate and clonazepam for treatment-resistant panic disorder.

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University Hospital, Monterrey, Mexico.

Abstract

Sodium valproate (VA) and clonazepam (CLZ) were combined in the treatment of 4 patients with panic disorders (PD) who were resistant to several antipanic drug treatments. A significant improvement was found in the symptomatology of these patients, but relapses occurred when CLZ dosage was reduced. A potentiation of the GABAergic properties of VA and clonazepam is postulated. This combined treatment could be advantageous for some treatment-resistant PD patients but needs to be studied further.

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