Abstract
The expression of mRNA for chemorepellent factors slit1 and slit2 in rat peripheral nerve regeneration was examined. The mRNA of slit2 increased when the continuity of basal lamina tubes was disrupted, not when it remained and the Slit2 protein was located in Schwann cells. These results suggest that disruption of the continuity of basal lamina tubes induces the expression of slit2 in Schwann cells during peripheral nerve regeneration.
MeSH terms
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Actins / biosynthesis
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Actins / genetics
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Animals
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Axons / metabolism
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Immunohistochemistry
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Intercellular Signaling Peptides and Proteins
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Molecular Sequence Data
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Nerve Crush
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Nerve Regeneration / genetics*
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Nerve Tissue Proteins / biosynthesis
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Nerve Tissue Proteins / genetics*
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Peripheral Nerves / metabolism*
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RNA, Messenger / biosynthesis
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RNA, Messenger / genetics
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Rats
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Receptors, Immunologic / genetics
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Reverse Transcriptase Polymerase Chain Reaction
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Roundabout Proteins
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Schwann Cells / metabolism
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Sciatic Nerve / injuries
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Sciatic Nerve / metabolism
Substances
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Actins
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Intercellular Signaling Peptides and Proteins
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Nerve Tissue Proteins
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RNA, Messenger
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Receptors, Immunologic
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Slit1 protein, mouse
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Slit homolog 2 protein