Cell. 2005 Dec 29;123(7):1191-8.

Fanconi anemia (cross)linked to DNA repair.

Niedernhofer LJ, Lalai AS, Hoeijmakers JH.

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Center for Biomedical Genetics, Medical Genetic Center, Department of Cell Biology and Genetics, Erasmus Medical Center, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.

Abstract

Fanconi anemia is characterized by hypersensitivity to DNA interstrand crosslinks (ICLs) and susceptibility to tumor formation. Despite the identification of numerous Fanconi anemia (FANC) genes, the mechanism by which proteins encoded by these genes protect a cell from DNA interstrand crosslinks remains unclear. The recent discovery of two DNA helicases that, when defective, cause Fanconi anemia tips the balance in favor of the direct involvement of the FANC proteins in DNA repair and the bypass of DNA lesions.

PMID:: 16377561; [PubMed - indexed for MEDLINE]

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