Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Alzheimer Res. 2005 Dec;2(5):541-51.

A randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer's type.

Author information

  • 1Department of Psychiatry and the Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA. lschneid@usc.edu

Abstract

CONTEXT:

Previous studies of Ginkgo biloba extract (GbE) in patients with various forms of cognitive impairment or dementia have shown promising results.

OBJECTIVE:

To determine the clinical efficacy of GbE in mild to moderate dementia of the Alzheimer type.

DESIGN:

Randomized, placebo-controlled, double-blind, parallel-group, multicenter trial.

SETTING:

Outpatient clinics of universities and private research centers specialized in dementia.

PATIENTS:

513 outpatients with uncomplicated dementia of the Alzheimer's type scoring 10 to 24 on the Mini-Mental State Examination and less than 4 on the modified Hachinski Ischemic Score, free of other serious illnesses and not requiring continuous treatment with any psychoactive drug.

INTERVENTION:

26-week treatment with GbE at daily doses of 120 mg or 240 mg or placebo.

MAIN OUTCOMES:

Cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-cog), Alzheimer's Disease Cooperative Study Clinical Global Impression of Change (ADCS-CGIC).

RESULTS:

There were no significant between-group differences for the whole sample. There was little cognitive and functional decline of the placebo-treated patients, however. For a subgroup of patients with neuropsychiatric symptoms there was a greater decline of placebo-treated patients and significantly better cognitive performance and global assessment scores for the patients on GbE.

CONCLUSION:

The trial did not show efficacy of GbE, however, the lack of decline of the placebo patients may have compromised the sensitivity of the trial to detect a treatment effect. Thus, the study remains inconclusive with respect to the efficacy of GbE.

Comment in

PMID:
16375657
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Bentham Science Publishers Ltd.
    Loading ...
    Write to the Help Desk