Presse Med. 2005 Dec 17;34(22 Pt 1):1710-2.

[Spontaneous skin necrosis from acquired protein S deficiency in a renal transplant recipient].

[Article in French]

Laurat E, Frouget T, Joyeux V, Arvieux C, Pommereuil M, Chevrant-Breton J.

Source

Service de médecine 1, Hôpital d'Avranches (50). elisabeth.laurat@ch-avranches-granville.fr

Abstract

INTRODUCTION:

Spontaneous skin necrosis revealed acquired protein S deficiency due to isotype G autoantibodies.

CASE:

This 31-year-old male renal transplant recipient, receiving immunosuppressive treatment, was hospitalized for necrotic purpural lesions. We were not able to detect any triggering factor. Sustained anticoagulant therapy remained essential to prevent new skin lesions and perhaps more thrombotic events.

COMMENTS:

This condition is rare in adulthood, but is well described in children's purpura fulminans, especially the post-varicella form. Its mechanism remains unclear.

PMID:: 16374391; [PubMed - indexed for MEDLINE]

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