Phytother Res. 2005 Dec;19(12):1069-70.

Antiviral properties of ent-labdene diterpenes of Andrographis paniculata nees, inhibitors of herpes simplex virus type 1.

Wiart C, Kumar K, Yusof MY, Hamimah H, Fauzi ZM, Sulaiman M.

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Department of Pharmacy, Faculty of Medicine, University of Malaya, Malaysia. christophe_wiart@yahoo.com

Abstract

Andrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide, ent-labdene diterpenes isolated from Andrographis paniculata showed viricidal activity against herpes simplex virus 1 (HSV-1). None of these compounds exhibited significant cytotoxicity at viricidal concentrations.

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