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Clin Neurophysiol. 2006 Feb;117(2):381-7. Epub 2005 Dec 20.

Electrophysiological correlates of cortico-subcortical interaction: a cross-frequency spectral EEG analysis.

Author information

  • 1Department of Psychonomics, Affective Neuroscience Section, Helmholtz Research Institute, Utrecht University, Heidelberglaan 2, 3584CS Utrecht, The Netherlands. d.schutter@fss.uu.nl

Abstract

OBJECTIVE:

Several studies have provided evidence for the notion that the coupling between slow and fast frequency in the EEG spectrum indicates cortico-subcortical cross-talk (CSC-ct). In addition, findings for increased limbic activation due to reduced cortical inhibition have recently been acquired. To get further insights into these mechanisms, the current study investigated whether CSC-ct would decrease as a function of increased slow (SW) or fast wave (FW) activity.

METHODS:

Resting state EEG recordings were obtained from 46 healthy, right-handed participants. CSC-ct was quantified by computing cross-frequency correlations between the power in the slow and fast frequency range. CSC-ct was compared between groups with relatively low and high SW activity and groups with relatively low and high FW activity.

RESULTS:

Relatively reduced SW, but not FW activity was associated with a significant coupling between slow and fast frequency EEG. Furthermore, relatively enhanced resting state SW activity was paralleled by slow and fast frequency EEG decoupling.

CONCLUSIONS:

These findings are in line with the notion that increased subcortical drive can go accompanied by reduced CSC-ct.

SIGNIFICANCE:

Cross-frequency EEG analyses might provide a unique approach to obtain novel insights into cortico-subcortical interactions in relation to affective and cognitive behavior.

PMID:
16371254
[PubMed - indexed for MEDLINE]
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