Expert Opin Biol Ther. 2006 Jan;6(1):23-37.

Pancreatic islet transplantation for treating diabetes.

Matsumoto S, Noguchi H, Yonekawa Y, Okitsu T, Iwanaga Y, Liu X, Nagata H, Kobayashi N, Ricordi C.

Source

Transplantation Unit, Kyoto University Hospital, Diabetes Research Institute Kyoto, Shogoin, Kyoto 606-8507, Japan. shinichi41@mopera.net

Abstract

Pancreatic islet transplantation is one of the options for treating diabetes and has been shown to improve the quality of life of severe diabetic patients. Since the Edmonton protocol was announced, islet transplantation have advanced considerably, including islet after kidney transplantation, utilisation of non-heart-beating donors, single-donor islet transplantation and living-donor islet transplantation. These advances were based on revised immunosuppression protocols, improved pancreas procurement and islet isolation methods, and enhanced islet engraftment. Further improvements are necessary to make islet transplantation a routine clinical treatment. To synergise efforts towards a cure for type 1 diabetes, a Diabetes Research Institute (DRI) Federation is currently being established to include leading diabetes research centres worldwide, including DRIs in Miami, Edmonton and Kyoto among others.

PMID:: 16370912; [PubMed - indexed for MEDLINE]

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Cited by 2 PubMed Central articles

Variables associated with islet yield in autologous islet cell transplantation for chronic pancreatitis. [Proc (Bayl Univ Med Cent). 2010]
Variables associated with islet yield in autologous islet cell transplantation for chronic pancreatitis.
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