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Hum Genet. 2006 Feb;118(6):691-4. Epub 2005 Dec 21.

Extreme skewing of X chromosome inactivation in mothers of homosexual men.

Author information

  • 1Department of Human Genetics, University of California-Los Angeles, Los Angeles, CA, USA. sbocklandt@mednet.ucla.edu

Abstract

Human sexual preference is a sexually dimorphic trait with a substantial genetic component. Linkage of male sexual orientation to markers on the X chromosome has been reported in some families. Here, we measured X chromosome inactivation ratios in 97 mothers of homosexual men and 103 age-matched control women without gay sons. The number of women with extreme skewing of X-inactivation was significantly higher in mothers of gay men (13/97=13%) compared to controls (4/103=4%) and increased in mothers with two or more gay sons (10/44=23%). Our findings support a role for the X chromosome in regulating sexual orientation in a subgroup of gay men.

PMID:
16369763
[PubMed - indexed for MEDLINE]
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