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Infect Immun. 2006 Jan;74(1):729-33.

Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms.

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  • 1Division of Genomic Medicine, F-Floor, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, United Kingdom.


Host-driven macrophage apoptosis contributes to innate immunity during bacterial infection. Neisseria meningitidis inhibits apoptosis in a variety of cells, but its impact on macrophage apoptosis is unknown. We demonstrate that N. meningitidis prevents macrophage apoptosis via genes encoding nitric oxide detoxification and a porin, PorB.

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