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    Ann Neurol. 2006 Feb;59(2):372-5.

    Migraine and MTHFR C677T genotype in a population-based sample.

    Scher AI, Terwindt GM, Verschuren WM, Kruit MC, Blom HJ, Kowa H, Frants RR, van den Maagdenberg AM, van Buchem M, Ferrari MD, Launer LJ.

    Source

    Department of Preventive Medicine and Biometrics, Uniformed Services University, Bethesda, MD 20814-4799, USA. ascher@usuhs.mil

    Abstract

    OBJECTIVE:

    Migraine with aura is associated with increased risk of stroke. The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples and with elevated homocysteine, a risk factor for stroke. We assessed the association of the MTHFR C677T variant with migraine and the mediating effect of cardiovascular risk factors and metabolic markers of genotype status.

    METHODS:

    We compared adult migraineurs with aura (MA; n = 187), without aura (MO; n = 226), and nonmigraineurs (n = 1,212) from the population-based Genetic Epidemiology of Migraine study.

    RESULTS:

    Compared with the wild-type genotype, the T/T genotype was associated with increased odds of MA (odds ratio [OR], 2.05; 95% confidence interval, 1.2-3.4; p < 0.006), with a trend of increasing numbers of T alleles (OR, 1.40; 95% confidence interval, 1.1-1.8; p < 0.007). ORs were slightly attenuated after adjusting for homocysteine.

    INTERPRETATION:

    Risk of MA is associated with MTHFR C674T homozygosity, independent of other cardiovascular risk factors.

    Comment in

    • MTHFR C677T polymorphism and migraine with aura. [Ann Neurol. 2006]
    PMID:
    16365871
    [PubMed - indexed for MEDLINE]

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      Cited by 23 PubMed Central articles

      • Structural brain changes in migraine. [JAMA. 2012]
        Structural brain changes in migraine.
        Palm-Meinders IH, Koppen H, Terwindt GM, Launer LJ, Konishi J, Moonen JM, Bakkers JT, Hofman PA, van Lew B, Middelkoop HA, et al. JAMA. 2012 Nov 14; 308(18):1889-97.
      • Migraine, cerebrovascular disease and the metabolic syndrome. [Ann Indian Acad Neurol. 2012]
        Migraine, cerebrovascular disease and the metabolic syndrome.
        Sinclair AJ, Matharu M. Ann Indian Acad Neurol. 2012 Aug; 15(Suppl 1):S72-7.
      • Pathophysiology of migraine. [Ann Indian Acad Neurol. 2012]
        Pathophysiology of migraine.
        Goadsby PJ. Ann Indian Acad Neurol. 2012 Aug; 15(Suppl 1):S15-22.
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