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Virology. 2006 Jan 5;344(1):221-9.

Fifty-three years since Hershey and Chase; much ado about pressure but which pressure is it?

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  • 1Molecular Genetics and Microbiology, Institute for Cell and Molecular Biology, The University of Texas, Austin, TX 78712, USA. Molineux@mail.utexas.edu

Abstract

The events that occur at the initiation of phage infection are discussed, from adsorption through DNA ejection from the virion into the cell. A new model for DNA translocation is described that not only overcomes difficulties associated with previous models of DNA ejection but also provides a mechanism by which both single-stranded genomes and internal phage proteins can be transported from the virion into the cell cytoplasm.

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