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Clin Neurol Neurosurg. 2006 Mar;108(3):290-4. Epub 2005 Dec 20.

Psychiatric manifestations of multiple sclerosis and acute disseminated encephalomyelitis.

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  • 1University Department of Neurology, Zagreb School of Medicine and University Hospital Center Zagreb, Kispatićeva 12, Zagreb, Croatia. mhabek@mef.hr


It is unusual for acute disseminated encephalomyelitis and multiple sclerosis to present as purely psychiatric disorders. We report five patients with such demyelinating diseases and symptoms of psychosis, depression or anxiety. The importance of excluding demyelination as the basis for these psychiatric disturbances is emphasized, especially in the presence of unexplained neurologic findings. The possible relationship between psychiatric symptoms and demyelinating disorders is explored.

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